E.R. (Ron) de Kloet

Academy professor of the Royal Netherlands Academy of Arts and Sciences, 

(em) professor Medical Pharmacology

LACDR / LUMC, Leiden University 



Professor Ron de Kloet is known for his discoveries in the science of stress and the brain.

For half a century he is fascinated by the question how stress hormones, that are critical for life, can change their action in the brain from protective to harmful, while enhancing vulnerability to stress-related disorders. De Kloet and colleagues demonstrated that this switch from a resilient to a vulnerable brain depends on the balance between activation and suppression of stress reactions which is under control of one single hormone: cortisol. This discovery has provided a novel treatment strategy of stress-related mental disorders aimed to promote a mechanism of resilience still present in the diseased brain.

From 1990  until 2009 he was professor of Medical Pharmacology at Leiden University/Medical  Center. The Department of Medical Pharmacology at the Leiden Academic Center for Drug Research with an outstanding research group )*  skilled in experiments from gene to behaviour with a translational perspective for application in drug development and medicine . From 2004 until today he is appointed Academy Professor of the Royal Netherlands Academy of Arts and Sciences at the LACDR, Leiden University and the Department of Endocrinology & Metabolism, LUMC.


Spin-off:  Dynacorts Therapeutics BV          <http://www.dynacorts.com>

publication record:                                         <http://scholar.google.com/citations?user=Eao7yZIAAAAJ>


)* Department of Medical Pharmacology              <http://medicalpharmacology.leidenuniv.nl>

The site contains a description of the history of Pharmacology in The Netherlands & Leiden by Erik L. Noach and includes the publication record of the Leiden Department of Medical Pharmacology (1904 - 2014) containing more than 2000 titles. The last professors/chairs were  Samuel de Jong (1898-1976), Eric Noach (1921-2008) & Peter van Rees(1928-2012) and finally Ron de Kloe (1944- ). The Leiden signature always has been in the endocrinology and neurosciences.  For curiosity also the research agenda, list of personnel and alumni is given as of 2012 when the department was terminated by the Faculty of Science (Dean S Verduyn Lunel) and part of the personnel was transfered to Leiden University Medical Center. With courtesy of Wout Meelis who kept the site up to date until 2014.

Contact:    <erdekloet@gmail.com>  e.kloet@lacdr.leidenuniv.nl> E.R.de_Kloet.ENDO@lumc.nl