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Author of  > 600 Publications, Editor 6 books, 1 co-authored monograph.

Promotor 56 PhD theses.    Citations >37000  (Web of Science),   >49000 (Google)    

H factor 97 (Web of Science) / 113 (Google Scholar)


Thesis, oratie, afscheidsrede

DE KLOET ER (1972) The distribution of dexamethasone in relation to its effect on pituitary-adrenal activity, Thesis, University of Utrecht, The Netherlands.

DE KLOET ER (1 november 1991) Evenwicht in een veranderende wereld. Oratie. Rijksuniversiteit Leiden.

DE KLOET (5 maart 2010)  Tussenbalans.  Afscheidsrede in Dutch & English. Universiteit Leiden.



VAN PRAAG HM, DE KLOET ER, J VAN OS Authors, (2004) Stress, the Brain and Depression. Cambridge University Press.  Monograph in English and Portugese editions.


Selected key publications until 2009

Reul JMHM; De Kloet ER  (1985) Two receptor systems for corticosterone in rat brain: microdistribution and differential accupation  Endocrinology 117: 6, 2505-2511.

Joels M and De Kloet ER (1989) Effects of glucocorticoids and norepinephrine in the Excitability in the hippocampus. Science 245: 1502-1505.

De Kloet ER. (1991) Brain Corticosteroid receptor balance and homeostatic control. Frontiers in Neuroendocrinology 12: 2, 95-164.

Oitzl M and De Kloet ER (1992) Selective corticosteroid-antagonists modulate specific aspects of spatial orientation learning. Behav. Neurosci. 106: 62-71.

Joels M and De Kloet ER (1992) Control of neuronal excitability by corticosteroid hormones. Trends in Neurosci. 15: 25-30,

De Kloet ER; Vreugdenhil E; Oitzl MS; Joëls M (1998). Brain corticosteroid receptor balance in health and disease  Endocrine Reviews 19: 3269-301.

Meijer OC, De Lange ECM, Breimer DD, De Boer AG, Workel JO and De Kloet ER (1998) Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139: 1789-1793.

 De Kloet ER, Oitzl MS; Joels M  (1999) Stress and cognition: are corticosteroids good or bad guys?  Trends in Neurosciences 22: 10, 422-426. 

De Kloet ER; Joels M; Holsboer F (2005) Stress and the brain: From adaptation to disease Nature Reviews Neuroscience 6: 6, 463-475.

Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meaney, M. J., De Kloet, E. R. Krugers H, Joels M  (2008). Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci., 28(23), 6037-6045

Joels, M., Karst, H., de Rijk, R. H., & De Kloet, E. R. (2008). The coming out of the brain mineralocorticoid receptor. Trends Neurosci., 31(1), 1-7.


Recent publications

de Kloet ER, Molendijk ML.Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism. Neural Plast. 2016:6503162. doi: 10.1155/2016/6503162.  

de Kloet ER, Otte C, Kumsta R, Kok L, Hillegers MH, Hasselmann H, Kliegel D, Joëls M. J Neuroendocrinol. STRESS and DEPRESSION a crucial role of the mineralocorticoid receptor2016, Aug 28 (8). doi: 10.1111/jne.12379.

De Kloet ER (2014) From Receptor Balance to Rational Glucocorticoid Therapy. Endocrinology 155: 2754-2769. doi: 10.1210/en.2014-1048.

Daskalakis NP, Diamantopoulou A, Claessens SE, Remmers E, Tjälve M, Oitzl MS, Champagne DL, de Kloet ER (2014) Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation. Psychoneuroendocrinology 39:39-57.

Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER (2013) The three-hit concept of vulnerability and resilience: toward understanding afaptation to early-life adversity outcome.  Psychoneuroendocrinology. 2013 Sep;38(9):1858-73. doi: 10.1016/j.psyneuen.2013.06.008.

Polman, JAE.; de Kloet, E.R.; Datson, NA.(2013) Two Populations of Glucocorticoid Receptor-Binding Sites in the Male Rat Hippocampal Genome. Endocrinology 154, 5, 1832-1844. 

Kruk MR, Haller J, Meelis W, de Kloet ER. Mineralocorticoid receptor blockade during rat's first violent encounter inhibits its subsequent propensity to violence. Behav Neurosci. 2013 Aug;127(4):505-14. doi: 10.1037/a0033553

Harris AP, Holmes MC, de Kloet ER, Chapman KE, Seckl JR (2013). Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour. Psychoneuroendocrinology. 38: 5, 648-658.

Polman JA, Hunter RG, Speksnijder N, van den Oever JM, Korobko OB, McEwen BS, de Kloet ER, Datson NA. Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History (2012). Endocrinology 153, 9, 4317-4327.

Claessens SE, Daskalakis NP, Oitzl MS, de Kloet ER (2012). Early handling modulates outcome of neonatal dexamethasone exposure. Horm Behav. 62:433-441

Klok MD, Giltay EJ, Van der Does AJ, Geleijnse JM, Antypa N, Penninx BW, de Geus EJ, Willemsen G, Boomsma DI, van Leeuwen N, Zitman FG, de KloetER, de Rijk RH (2011) A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females. Translational Psychiatry  1, e62.